1. Denomination

Vepesid

2. Active Substance

Etoposide

3. Indications for Use.

Should be used for treatment of lungs cancer, ootecoma and herminogene seminima, adrenal cortex cancer, acute monoblastic leukemia, urinary bladder cancer, leukemia of myelogenous, Kaposi’s sarcoma, lymphogranulomatosis, cancer of stomach, Non Hodgkin Lymphom, neuroblastoma, chorionepithelioma.

4. Action

Etoposide works by delaying the synthesis of DNA and also by suppressing the development of cells of tumor.

5. Posology and Administration

The administration of the medication and doses should be defined, depending on the regimen of current chemotherapy. For intravenous administration the drug should be used drip-fee by dissolving it in 0.9% NaCl solution for 30-60 minutes. The medication should be taken in the following doses: 1 – 100mg per sq.m per day from first to fifth day of treatment with repetition of cycles once in 3-4 weeks; 2 – 100-125mg per sq.m for first, third and firth days with repetition of courses once in 3 weeks; 3 – 50mg per sq.m for oral intake once a day for 3 weeks with repetition of cycles once in 4 weeks, or 100-200mg per sq.m, which should be taken for 5 days at three week interval. Only when the peripheral blood factors have been normalized, it is allowed to carry our refresher courses of therapy. Before using the medication intravenously it should be dissolved in 0.9% solution of 250ml of NaCl or in dextrose with 5% solution until the concentration of the medication dissolves to 0.2-0.4mg per ml. It is not allowed to contact pH of more than 8 buffered water solution.

6. Counterindications

Failure of liver or kidney, hypersensitivity, bad distress of formation of cerebral blood, acute infections of virus, bacterial and fungal nature (including chicken pox and herpes).
Epilepsy, alcoholism, childhood age below 2 years, due to the fact that efficiency and safety of use of the medication for treatment of children has not been determined yet.

7. Should Be Taken with Precautions, if…

The medication should be taken with caution for treatment of patients with arrhythmia, as well as for patients who have failure of liver or kidney (correction of dose is necessary, as well as regular control of functioning of kidney).
The medication should only be taken under control of medical specialist. Regular monitoring of composition of blood is required before starting treatment. It should be don’t before starting each course. If patient has gone through chemo-therapy or radiation treatment before starting treatment with Etoposide, there might be a need to correct the dosage for treatment depending on the distress function of marrow bone.
If administering Etoposide, it is required to use safety masks, whites, glasses, and gloves in the process of application. If the medication gets in contact with mucus coating and skin, the parts which got in contact should be rinsed with soap and water as soon as possible.

8. Interface with Other Medications

Etoposide should not be taken without an order from a doctor at no circumstances. Any kinds of use of this drug, including combined application with any other medicines should be determined by treating doctor.

9. Overdosing

There were no cases until now of humans getting overdosed on Etoposide. It is possible, that in case of overdosage the medication will cause toxic effects on intestinal tract and blood.

10. Side Effects

Local reactions: phlebitis which can be caused by intravenous introduction, local penetration of medication under skin and intravenous introduction may cause locally-penetration action which can reach the level of necrosis of surrounding tissues. Side effects on blood forming organs: fall of the number of granulocytes and leukocytes varying depending on the dose used for injection. It can be used as the major toxic evidence that confines the dose.
Side effects on digestive system: vomiting, nausea, moreover there are noticed diarrhea, stomatitis, abdominal pains, gullet inflammation, gorge, inflammatory processes in the mouth cavity, gullet, anorexia, larynx. Side effects on cardio-vascular system: temporary lowering of arterial tension. Reactions of allergies: tachycardia, chilly sensation, panting of low arterial tension, bronchial spasm. Side effects on skin integument: inversive baldness, sometimes it results in hair loss. Rare: itching, pigmentation, radiation dermatitis. Other side effects: rare – increased fatigability, drowsiness, after-taste in mouth, cough caused by disorder of lungs, peeling, malign exudative erythema (Stevens-Johnson syndrome), optic neuritis, muscle convulsion, amaurosis fugax of cortical genesis, often nocturnal urination, metabolic acidosis.

11. Pregnancy and Lactation

The medication is not recommended for use in the period of lactation and pregnancy.

12. Driving

The medication should not be used by people who are involved in driving and operating machinery.

Q. After pressing the button "Add to Cart" I get on other site, why?
A. All operations at order of Vepesid are carried out with our secure transaction server.Your data is safely encrypted and is safe from any unauthorized access.

Q. What is your privacy policy?
A. We are fully dedicated to your privacy and security. Please refer to the current privacy policy in the terms & conditions section of our order page. Rest assured that our online order system makes use of the latest Security encryption technology to ensure that your credit card information is submitted safely and with the highest level of protection. All of our computer systems undergo regular security checks to ensure that our ordering system is properly protected.

Q. How do I track my order of Vepesid ?
A. At this time, your order is sent through Registered Mail, which provides delivery confirmation but not real-time tracking.If you need to know the status of order Vepesid or ask for a reshipment, please do not hesitate to get in touch with us.You are provided with real-time order status updates via our order status form, found on the left-hand side of the screen.

Q. How do I cancel my order of Vepesid ?
A. If you wish to cancel your order, you must let us know before 11am EST the following day. We will not be able to cancel any orders after this time. For all cancellations, please contact us.

Q. Can you tell me if I should be taking Vepesid ? Or, will it work for me?
A. We cannot advise you in any capacity in this matter. You should not take any medication without consulting a physician first.

Q. What is your returns policy?
A. By law, we regret that we are unable to accept returned pharmaceuticals. If your purchase is defective in any way, we will be pleased to replace it at no cost to you.

Q. What is your refund policy
A. Refunds are solely at our discretion. If you are not satisfied with the product or service provided, contact us immediately via email with your order number. We will investigate and work hard to resolve the issue to your satisfaction. Sometimes this can take up to 10 business days. If the matter cannot be resolved, we will issue refunds as necessary.

Q. What is your cancellation policy
A. We debit your Credit Card only once we have shipped your order. Therefore, if you wish to cancel your order prior to us charging your card you will be able to do so without penalty. Once your order has been shipped we will be unable to cancel your order.

Q. What about importing of Vepesid to my country ?
A. Importation of prescription medication is legal in most countries (including the US, UK, France, Spain, Hong Kong, Japan and S. Korea) provided the medication is for personal use and is not a controlled substance. If you are in doubt about the situation in your country, check with your local Post Office.